We thank Fermentek for the information,
the free Nonactin granted for our project,
and most of all, the moral support |
Link friends <![CDATA[<ol><li><p align="left"><a href="http://17dmag.imess.net">17dmag </a></li><li><p align="left"><a href="http://7aad.yoll.net">7aad </a></li><li><p align="left"><a href="http://actinomycin.imess.net">actinomycin </a></li><li><p align="left"><a href="http://aflatoxin-b1.yoll.net">alfatoxin-b1 </a></li><li><p align="left"><a href="http://aflatoxin-b2.yoll.net">aflatoxin-b2 </a></li><li><p align="left"><a href="http://aflatoxin-g1.sinfree.net">aflatoxin-g1 </a></li><li><p align="left"><a href="http://aflatoxin-g2.hotusa.org">aflatoxin-g2 </a></li><li><p align="left"><a href="http://aflatoxin-m1.yoll.net">aflatoxin-m1 </a></li><li><p align="left"><a href="http://aflatoxin-m2.yoll.net">aflatoxin-m2</a></li><li><p align="left"><a href="http://anisomycin.sinfree.net">anisomycin </a></li><li><p align="left"><a href="http://ascomycin.my-age.net">ascomycin </a></li><li><p align="left"><a href="http://Blyukher.imess.net">Blukher</a></li><li><p align="left"><a href="http://Bukharin.imess.net">Bukharin</a></li><li><p align="left"><a href="http://dybenko.maclenet.com">dybenko</a></li><li><p align="left"><a href="http://frinovsky.imess.net">frinovsky </a></li><li><p align="left"><a href="http://geldanamycin.fateback.com">geldanamycin </a></li><li><p align="left"><a href="http://k252a.enacre.net">k252a </a></li><li><p align="left"><a href="http://k252b.bebto.com">k252b </a></li><li><p align="left"><a href="http://kt5720.deep-ice.com">kt5720 </a></li><li><p align="left"><a href="http://kt5823.undonet.com">kt5823</a></li><li><p align="left"><a href="http://leptomycin.bebto.com">leptomycin </a></li><li><p align="left"><a href="http://Link-Exchange.yoll.net">Link-Exchange</a></li><li><p align="left"><a href="http://mithramycin.noneto.com">mithramycin </a></li><li><p align="left"><a href="http://mitomycin.enacre.net">mitomycin </a></li><li><p align="left"><a href="http:// nonactin.yoll.net">nonactin</a></li><li><p align="left"><a href="http://Ochratoxin.fateback.com">Ochratoxin</a></li><li><p align="left"><a href="http://parthenolide.my-age.net">parthenolide </a></li><li><p align="left"><a href="http://snorring.deep-ice.com">Snorring</a></li><li><p align="left"><a href="http://staurosporine.hotusa.org">staurosporine </a></li><li><p align="left"><a href="http://tinnitus.hotusa.org">tinnitus </a></li><li><p align="left"><a href="http://trichostatin.sinfree.net">trichostatin </a></li><li><p align="left"><a href="http://tukhachevsky.fateback.com">tukhachevsky </a></li><li><p align="left"><a href="http://verruculogen.maclenet.com">verruculogen </a></li><li><p align="left"><a href="http://vomitoxin.fateback.com">vomitoxin </a></li><li><p align="left"><a href="http://wortmannin.yoll.net">wortmannin </a></li><li><p align="left"><a href="http://yakir.sinfree.net">yakir </a></li><li><p align="left"><a href="http://yegorov.sinfree.net">yegorov </a></li><li><p align="left"><a href="http://yezhov.sinfree.net">yezhov </a></li><li><p align="left"><a href="http://zearalenone.imess.net">zearalenone </a></li></ol><p align="left"><hr color="#008000" size="5" align="left"><p align="left">Here come some links to top-rated hrefs, such as Microsoft, wikipedia, Google and Yahoo :<a href="http://www.google.co.il/">google</a>, <a href="http://www.microsoft.com/en/us/default.aspx">microsoft</a>, <a href="http://www.yahoo.com/">yahoo</a>, <a href="http://en.wikipedia.org/wiki/Main_Page">wikipedia</a></p><hr color="#008000" size="5" align="left"><p align="left">Now come links to these of fermentek product pages, that are needy : .<a href="http://www.fermentek.co.il">the homepage of fermentek</a>, <a href="http://www.fermentek.co.il/FK506.htm">FK506 or tacrolimus</a>, <a href="http://www.fermentek.co.il/05-products.htm">products of Fermentek: staurosporine, K252A, aflatoxin</a>, <font face="Verdana" size="2"><a href="http://www.fermentek.co.il/rapamycin.htm">Sirolimus (Rapamycin)</a></font></p><p align="left">And other link beggars:</p><p align="left"><a href="http://Tinnitus.itgo.com">Tinnitus. about some guys that had tinnitus ]]> | 4: Eur J Biochem. 1981 Nov;120(2):263-6.
Uptake of thallous ions by mitochondria is stimulated by nonactin but not by respiration alone.
Skulskii IA, Saris NE, Savina MV, Glasunov VV.
Nonrespiring rat-liver mitochondria swell in media containing high concentrations of thallous nitrate, indicating passive penetration of Tl+. This swelling could be further stimulated by 10 nM or more nonactin while even 1 microM valinomycin was without effect. Nonactin was also much more potent than valinomycin in stimulating swelling of respiring mitochondria in the presence of thallous acetate. It is evident that nonactin acts as a potent ionophore of Tl+ able to promote both the passive and energized uptake of Tl+ in mitochondria. The distribution of Tl+, present in trace concentrations below 1 mM, was measured during energisation by respiration both in the presence and absence of ionophores. Respiration induced net uptake of Tl+ only in the presence of ionophores, though Tl+ as a permeant cation was expected to sense respiration-induced changes in the membrane potential. The data may be interpreted as indicating that no transmembrane potential is formed upon energisation, but localized fields, which are able to interact with the lipophilic ionophore complexes of Tl+, but not with the hydrophilic cation Tl+. This interpretation is valid only if thermodynamic equilibrium has been reached.
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