We thank Fermentek for the information,
the free Nonactin granted for our project,
and most of all, the moral support |
Link friends <![CDATA[<ol><li><p align="left"><a href="http://17dmag.imess.net">17dmag </a></li><li><p align="left"><a href="http://7aad.yoll.net">7aad </a></li><li><p align="left"><a href="http://actinomycin.imess.net">actinomycin </a></li><li><p align="left"><a href="http://aflatoxin-b1.yoll.net">alfatoxin-b1 </a></li><li><p align="left"><a href="http://aflatoxin-b2.yoll.net">aflatoxin-b2 </a></li><li><p align="left"><a href="http://aflatoxin-g1.sinfree.net">aflatoxin-g1 </a></li><li><p align="left"><a href="http://aflatoxin-g2.hotusa.org">aflatoxin-g2 </a></li><li><p align="left"><a href="http://aflatoxin-m1.yoll.net">aflatoxin-m1 </a></li><li><p align="left"><a href="http://aflatoxin-m2.yoll.net">aflatoxin-m2</a></li><li><p align="left"><a href="http://anisomycin.sinfree.net">anisomycin </a></li><li><p align="left"><a href="http://ascomycin.my-age.net">ascomycin </a></li><li><p align="left"><a href="http://Blyukher.imess.net">Blukher</a></li><li><p align="left"><a href="http://Bukharin.imess.net">Bukharin</a></li><li><p align="left"><a href="http://dybenko.maclenet.com">dybenko</a></li><li><p align="left"><a href="http://frinovsky.imess.net">frinovsky </a></li><li><p align="left"><a href="http://geldanamycin.fateback.com">geldanamycin </a></li><li><p align="left"><a href="http://k252a.enacre.net">k252a </a></li><li><p align="left"><a href="http://k252b.bebto.com">k252b </a></li><li><p align="left"><a href="http://kt5720.deep-ice.com">kt5720 </a></li><li><p align="left"><a href="http://kt5823.undonet.com">kt5823</a></li><li><p align="left"><a href="http://leptomycin.bebto.com">leptomycin </a></li><li><p align="left"><a href="http://Link-Exchange.yoll.net">Link-Exchange</a></li><li><p align="left"><a href="http://mithramycin.noneto.com">mithramycin </a></li><li><p align="left"><a href="http://mitomycin.enacre.net">mitomycin </a></li><li><p align="left"><a href="http:// nonactin.yoll.net">nonactin</a></li><li><p align="left"><a href="http://Ochratoxin.fateback.com">Ochratoxin</a></li><li><p align="left"><a href="http://parthenolide.my-age.net">parthenolide </a></li><li><p align="left"><a href="http://snorring.deep-ice.com">Snorring</a></li><li><p align="left"><a href="http://staurosporine.hotusa.org">staurosporine </a></li><li><p align="left"><a href="http://tinnitus.hotusa.org">tinnitus </a></li><li><p align="left"><a href="http://trichostatin.sinfree.net">trichostatin </a></li><li><p align="left"><a href="http://tukhachevsky.fateback.com">tukhachevsky </a></li><li><p align="left"><a href="http://verruculogen.maclenet.com">verruculogen </a></li><li><p align="left"><a href="http://vomitoxin.fateback.com">vomitoxin </a></li><li><p align="left"><a href="http://wortmannin.yoll.net">wortmannin </a></li><li><p align="left"><a href="http://yakir.sinfree.net">yakir </a></li><li><p align="left"><a href="http://yegorov.sinfree.net">yegorov </a></li><li><p align="left"><a href="http://yezhov.sinfree.net">yezhov </a></li><li><p align="left"><a href="http://zearalenone.imess.net">zearalenone </a></li></ol><p align="left"><hr color="#008000" size="5" align="left"><p align="left">Here come some links to top-rated hrefs, such as Microsoft, wikipedia, Google and Yahoo :<a href="http://www.google.co.il/">google</a>, <a href="http://www.microsoft.com/en/us/default.aspx">microsoft</a>, <a href="http://www.yahoo.com/">yahoo</a>, <a href="http://en.wikipedia.org/wiki/Main_Page">wikipedia</a></p><hr color="#008000" size="5" align="left"><p align="left">Now come links to these of fermentek product pages, that are needy : .<a href="http://www.fermentek.co.il">the homepage of fermentek</a>, <a href="http://www.fermentek.co.il/FK506.htm">FK506 or tacrolimus</a>, <a href="http://www.fermentek.co.il/05-products.htm">products of Fermentek: staurosporine, K252A, aflatoxin</a>, <font face="Verdana" size="2"><a href="http://www.fermentek.co.il/rapamycin.htm">Sirolimus (Rapamycin)</a></font></p><p align="left">And other link beggars:</p><p align="left"><a href="http://Tinnitus.itgo.com">Tinnitus. about some guys that had tinnitus ]]> | 10: FEMS Microbiol Lett. 2000 Feb 1;183(1):171-5.
Nonactin biosynthesis: the potential nonactin biosynthesis gene cluster contains type II polyketide synthase-like genes.
Walczak RJ, Woo AJ, Strohl WR, Priestley ND.
The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA.
Nonactin is the parent compound of a group of highly atypical polyketide metabolites produced by Streptomyces griseus subsp. griseus ETH A7796. In this paper we describe the isolation, sequencing, and analysis of 15 inverted question mark omitted inverted question mark559 bp of chromosomal DNA, containing the potential nonactin biosynthesis gene cluster, from S. griseus subsp. griseus ETH A7796. Fourteen open reading frames were observed in the DNA sequence. Significantly, type II polyketide synthase (PKS) homologues were discovered in an apparent operon structure, which also contained the nonactate synthase gene (nonS), clustered with the tetranactin resistance gene. The deduced products of two of the genes (nonK and nonJ) are quite unusual ketoacyl synthase (KAS) alpha and KASbeta homologues. We speculate that nonactic acid, the polyketide precursor of nonactin, is synthesized by a type II PKS system.
PMID: 10650222 |
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